The Doctor Series · No. 5

When your body isn’t recovering the way it used to.

Inflammation, recovery and persistent symptoms. Much of this has an ordinary explanation. Some of it is the early sign of an inflammatory or autoimmune condition, and those are far easier to manage when they are recognised early.

96%

of 80-year-olds with no back pain at all show disc degeneration on a scan.

13.8%

of people aged twelve and over have a positive ANA test, and most have no autoimmune disease.

63%

lower odds of a raised CRP in people who ate the most fibre, compared with those who ate the least.

There is often a point in midlife when the body stops bouncing back. A hard session leaves you sore for days instead of hours, a minor niggle turns into months of pain, or you collect symptoms, such as tiredness, aching joints, a rash or an unsettled gut, that nobody has tied together. Much of this has an ordinary explanation, such as too little sleep, too much load or not enough fuel.

Think of inflammation as the body’s fire brigade. When there is an injury, an infection or a threat, it arrives, puts the fire out and goes home. The trouble starts when it doesn’t leave, and the signs can be as vague as waking tired, brain fog, bloating or weight that won’t shift.

What the blood tests can and can’t tell you.

CRP rises within hours of an infection, injury or flare and falls quickly once the cause settles, so it shows what is happening now. ESR changes more slowly and is also raised by age and anaemia. Both tell you that inflammation is present somewhere, but not where or why. A raised CRP after a cold or a hard training block usually settles, so the right step is often to repeat it once you are well. Normal markers do not rule everything out either, because lupus and early arthritis can both be active with a normal CRP. Inflammation also raises ferritin, which can hide true iron deficiency.

Turning the fire down: the base first.

Before anyone reaches for a special test or a supplement, the rule is to get the base right first, then we can get fancy. Cut back on alcohol and stop smoking. Eat deep-sea fish about four times a week, or take fish oil; in a pooled analysis of 68 trials, marine omega-3 supplements lowered CRP. Eat the fibre in vegetables, legumes and wholegrains that feeds the gut; in a year-long study of 524 adults, those who ate the most fibre were 63 per cent less likely to have a raised CRP. Pick up a heavy weight, because working muscle releases myokines that have anti-inflammatory effects. And sleep: in more than 50,000 people, disturbed sleep was linked with higher CRP. Going to bed at eleven with the alarm at half past five cannot give you eight hours.

AlcoholDrink less, stop smoking
FishOily fish about four times a week, or fish oil
FibreVegetables, legumes and wholegrains
LiftingHeavy weights: muscle releases myokines
SleepEnough hours in bed to get the sleep
Inflammation turned down. Get the base right first, then we can get fancy.

Recovery, tendons and scans.

Soreness for a day or two after hard training is repair, much of it done in deep sleep. Recovery that has slowed over months usually means the balance between load and recovery has tipped, through short sleep, a training load that has crept up, life stress or not eating enough to fuel the work. Tendons are often managed the wrong way. They get stronger with load, not rest: in a trial of 58 people with long-standing Achilles pain, twelve weeks of heavy slow resistance training, slow and heavy calf raises three times a week with the weight increased as the tendon allowed, improved pain and function, and the gains held at one year. A flare along the way is normal, and recovery takes three to six months.

Scans can mislead as easily as blood tests. Disc degeneration shows up on the scans of most people with no back pain at all, and the proportion rises steadily with age. Imaging is most useful when its result will change the plan.

37%
52%
68%
80%
88%
93%
96%
20
30
40
50
60
70
80

Disc degeneration on scans of people with no back pain at all, by age.

Some patterns point to inflammation rather than wear and tear: visibly swollen joints, morning stiffness lasting more than an hour, and pain where tendons attach to bone, such as the heel. For back pain, five features stand out.

Started before age 40
Came on gradually
Better with exercise
No better with rest
Pain at night, eases on rising
Four or more: inflammatory back pain is likely.

Connecting symptoms across the body.

Many people see a different practitioner for each problem: a physiotherapist for the knee, a dermatologist for the rash, a gastroenterologist for the gut and a GP for the tiredness. It is like calling a different tradesperson for every room when the fault is in the wiring. Our approach is to cluster the findings rather than chase each one, because three small clues pointing the same way say far more than any one alone. Antibody tests need the same care. A positive ANA is found in about one in seven people aged twelve and over, and most of them have no autoimmune disease.

Tiredness, bloating, iron deficiency
→
Coeliac disease
Back pain with a red, painful eye, psoriasis or bowel symptoms
→
Spondyloarthritis
Dry eyes and mouth, joint pain, fatigue
→
Sjögren’s disease
Knuckle pain, high transferrin saturation, low energy, low libido
→
Inherited iron overload
Poor recovery, frequent illness, low libido, stress fractures
→
Under-fuelling

Recognised patterns that link symptoms across different systems, and the condition each pattern can suggest.

Some symptoms need same-day attention: a hot, swollen joint with a fever, or, in people over 50, a new headache with scalp tenderness, jaw pain on chewing or a change in vision.

An illustrative example, not a real patient

A 38-year-old runner has had pain in both Achilles tendons for a year, despite rest, physiotherapy and an injection. He also has back stiffness that lasts more than an hour each morning and eases once he starts running, he had a red, painful eye eighteen months ago, and his bowels have been unsettled. His CRP is normal. Each problem has been treated as a separate overuse injury. Read together, they describe axial spondyloarthritis, and the normal CRP does not exclude it. The next steps are a blood test for HLA-B27, a genetic marker carried by most people with this condition, an MRI of the pelvic joints and referral to a rheumatologist, because effective treatment exists and his tendon programme will work far better once the inflammation is controlled.

Axial spondyloarthritis. HLA-B27 test, MRI of the pelvic joints, rheumatologist referral.
The take-home message
  1. Most slow recovery has an ordinary cause, so fix the base first: sleep, alcohol, oily fish, fibre and lifting.
  2. Blood tests and scans only make sense alongside your story, and a normal CRP does not rule out inflammatory disease.
  3. When symptoms in different parts of the body keep piling up, ask one doctor to read them together.
What we do differently

One doctor, connecting the dots.

At My Performance Doctor, one doctor looks at your symptoms, results, training and history together, starts with the base, and looks harder when the pattern says the base is not the whole story. If you have a collection of symptoms that nobody has connected, a call with Robyn is a good place to start.

More from our doctors

Get the next one in your inbox

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Sources
  1. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805-1812.
  2. Meeusen R, et al. Prevention, diagnosis, and treatment of the overtraining syndrome. Med Sci Sports Exerc. 2013;45(1):186-205.
  3. Mountjoy M, et al. 2023 International Olympic Committee’s consensus statement on Relative Energy Deficiency in Sport (REDs). Br J Sports Med. 2023;57(17):1073-1097.
  4. Beyer R, et al. Heavy slow resistance versus eccentric training as treatment for Achilles tendinopathy: a randomized controlled trial. Am J Sports Med. 2015;43(7):1704-1711.
  5. Brinjikji W, et al. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. AJNR Am J Neuroradiol. 2015;36(4):811-816.
  6. Sieper J, et al. New criteria for inflammatory back pain in patients with chronic back pain (ASAS). Ann Rheum Dis. 2009;68(6):784-788.
  7. Satoh M, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum. 2012;64(7):2319-2327.
  8. Adams PC, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352(17):1769-1778.
  9. Li K, et al. Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor α: a meta-analysis. PLoS One. 2014;9(2):e88103.
  10. Ma Y, et al. Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr. 2006;83(4):760-766.
  11. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88(4):1379-1406.
  12. Irwin MR, et al. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis. Biol Psychiatry. 2016;80(1):40-52.
  13. My Performance Doctor clinical playbooks, drawing on UpToDate and Western Victoria HealthPathways.

This article is general information and is not a substitute for individual medical advice. From the doctors at My Performance Doctor.